Avaliação renal de cães naturalmente infectados por Leishmania SSP e tratados com Milteforan® (Miltefosina): aspectos ultrassonográficos modo B e Doppler

Abstract

Leishmaniasis is a zoonotic disease caused by an intracellular protozoan of the genus Leishmania. Ultrasound is a noninvasive diagnostic modality, which can detect several alterations early. The objective of this work is to identify the alterations of parenchyma and renal hemodynamics, through the use of ultrasound evaluation in B and Doppler mode, of dogs with CVL treated with miltefosine. Thirty animals were divided into three groups. With the first formed by ten dogs without CVL (G1) the second with ten dogs with CVL not treated with miltefosine (G2) and the third formed by dogs with CVL treated with miltefosine (G3). Blood samples were collected from the animals selected for biochemical analysis of urea and creatinine, measurement of systemic blood pressure (SBP) was performed by vascular Doppler and ultrasound was performed for the complete renal evaluation of the renal parenchyma with Mode B and hemodynamic indexes with color Doppler. Presence of nephropathy were found relevant for animals in G2 and G3. Five animals from G2 and three from G3 presented IR values greater than 0.70 in the right and left renal arteries, G1 presented lower values. Even with some ultrasound and hemodynamic alterations, the Values of U and C were within normal limits for the species, however, the animals treated with Milteforan® (miltefosine) presented lower than the untreated values of the species. The mean IR of animals with CVL were higher than that of animals without the disease, showing no difference between animals with treated and untreated CVL. Animals with untreated leishmaniasis presented higher SBP values than animals treated with Milteforan® (miltefosine)