Neoplasias mamárias em cadelas: estudo dos fatores clínico-patológicos e identificação de anormalidades hematológicas e bioquímicas

Abstract

Canine mammary tumours are very common in the adult a elderly female dogs. Nevertheless, few are the studies evaluating the clinicopathological and laboratory variables in this disease. The aim of this study was to evaluate such variables in canine mammary tumors addition to identifying hematological and biochemical changes related to the paraneoplastic syndrome (SPN) in female dogs. Thus, 58 female dogs data were obtained with suspected breast tumors treated at the Veterinary Hospital “Francisco Uchôa Lopes” to clinicopathological assessment beyond the obtaining the same tumor samples for histopathological examination. Histopathological analysis confirmed 51 female dogs with malign and benign lesions mammary glands, of which 42 (72.41%) were referring to malign mammary lesions, and the mixed histological origin most represented by carcinomas in mixed tumors, followed by epithelial tumors more represented by tubular carcinomas. Only 9 (15.52%) female dogs had benign tumors, with significant frequency to the benign mixed tumors (5 / 8.62%) and fibroadenomas (3 / 5.20%). It was observed also that the mean age was 10.3 years featuring animals middle age to seniors. In continuity, been found that the most frequent breeds were the Poodle (27.45%), SRD (33.33%) and German Shepherd (9.80%) and that these were using ration-based ration and homemade food (66.7%). Still, not castrated female dogs showed in large amount (72.54%) and few had used contraceptive (5.9%), was majority presence in both of malignant lesions. In addition, the female dogs presented significant anemia, hypoalbuminemia and a tendency to elevation of serum calcium levels when assessed disease progression, especially for the later stages. The findings show an increased frequency of malignant lesions in female dogs carriers of mammary tumors by suggesting the need to be accomplished to staging of such animals and follow up of potential laboratory abnormalities indicative of paraneoplastic syndrome, contribute thereby to the perception of disease progression.