Estudo fitoquímico e atividade leishmanicida in vitro do extrato bruto de Arrabidaea chica (Humb. & Bonpl.) Verlot

Abstract

The treatment for leishmaniasis established for more than one hundred years has few drugs, and these should be evaluated for toxicity and adverse effects to the patient, with some cases of resistance have been reported. The chemical diversity and the vast range of bioagents derived from plants has led to the creation of hundreds of pharmaceutical drugs, many even have leishmanicidal activity. The Arrabidaea chica, known as “pariri” has many active metabolites with antiinflammatory, astringent and therapeutics properties. We carried out conducted a phytochemical study and evaluation in vitro leishmanicidal activity of the gross extract Arrabidaea chica. The extracts of the leaves and stem of Arrabidaea chica (Humb. & Bonpl.) Verlot had income of 59,2% and 3,33% respectively. The preliminary phytochemical screening showed that the extracts are flavonoids, phenolics, tannins, anthocyanins and chalcones. The extract from the leaves of Arrabidaea chica (Humb. & Bonpl.) Verlot demonstrated activity against promastigote forms os Leishmania amazonensis at a dosage of 500 μg/ml. The gross extract of Arrabidaea chica (Humb. & Bonpl.) Verlot showed cytotoxicity at a concentration of 189,9 μg/ml. The gross extract from the leaves of Arrabidaea chica is active against promastigotes of L. amazonensis in vitro model for further research and promising treatment options for leishmaniasis.