Efeito cicatrizante da geléia real in natura em feridas cutâneas induzidas experimentalmente em caprinos

Abstract

This research purposed to evalute the effect of healing of royal jelly in nature in skin wound induced experimentally in goats. Used fifty goats, S.R.D, females, with age rangin from eigtheen to twenty-four months, divided into tree groups of five animals. The skin wounds were performed in pit paralombar right and left and the animals were subjected the following treatments: control group (CG) - animals treated with saline solution to 0.9%, group royal jelly (GG) - animals treated with royal jelly in nature and healing pomade group (GP) – animals treated of pomade consists of desoxirribonuclease to 6.66%, fibrolisina 0.1% and clorafenicol to 1%. The wounds were evaluated macroscopically for ten consecutive days ,measured every wenty-fou hours and examined histologically at 2, 6 and 10 postoperative day using a computerized image analyser of Leica Qwin D-1000, version 4.1(Cambridge, UK). The results revealed that macroscopically there was no difference in how long the healing between groups and showed no difference in the appearance of the evolution of the wound. The group of royal jelly presented a contraction average percentage of 84% better than the control group (75%) in group of pomade (77%). Microscopically there was no statistical difference as the quantification of neutrophils and macrophages in both groups. At quantify of collagen, the group GC presented average of 229μm2, the group GG presented 236μm2 and group GG presented 215μm2 at 10º day p.o. While, on the group of royal jelly and the group of pomade there was greater proliferation of collagen and epithelization the wounds. Therefore, it is concluded that despite the macroscopic and microscopic aspects submit similar results between the groups, the group of royal jelly showed greater contraction of the area of the wound, reepithelization complete with greater proliferation of collagen can be an alternative in the treatment of wounds.