https://repositorio.uema.br/jspui/handle/123456789/2517 2026-04-10T20:07:37Z https://repositorio.uema.br/jspui/handle/123456789/5571 Título: Análise da presença de Prevotella em câncer cervical e câncer de cabeça e pescoço: uma revisão sistemática da literatura e análise in silico Abstact: Cervical cancer (CC) and head and neck cancer (HNC) represent a significant public health problem, especially in developing countries, and are frequently associated with infection by Human Papillomavirus (HPV). In addition to the viral etiology, recent evidence has pointed to the involvement of the microbiome, particularly bacteria of the genus Prevotella, in the progression of these neoplasms. Therefore, the aim of this study was to analyze the presence and potential role of Prevotella in CC and HNC through a systematic literature review and in silico approaches. The methodology involved searching the PubMed, Scopus, and ScienceDirect databases, following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. After screening 609 studies, six observational articles met the inclusion criteria. Data were organized into tables and evaluated for methodological quality using the Joanna Briggs Institute (JBI) tool. Additionally, in silico analyses were performed to assess Prevotella abundance and differentially expressed genes in HNC samples. The results show that Prevotella is primarily associated with microbial dysbiosis, HPV persistence, and inflammation in both cancers. The in silico analysis revealed a significant difference in Prevotella abundance between the tumor and adjacent tissue groups (p < 2.2e-16) and identified 1,416 altered genes shared between CC and HNC. Among these, three genes (LAMP3, ISG15, and IL6) showed a direct relationship with the presence of the bacterium, being involved in inflammatory pathways and immune evasion. These findings highlight the potential influence of Prevotella in tumor epithelial microenvironments, contributing to the progression of both CC and H 2025-06-24T00:00:00Z https://repositorio.uema.br/jspui/handle/123456789/5547 Título: Presença de Chlamydia trachomatis em cânceres associados ao HPV: uma Revisão Sistemática Abstact: Human papillomavirus (HPV) is one of the main etiological agents of cervical cancer (CC), whose malignant transformation involves persistent infection and integration of viral DNA into the host genome. However, carcinogenesis also requires the involvement of other infectious agents, such as Chlamydia trachomatis (CT), a sexually transmitted bacterium associated with chronic inflammation and viral persistence in cancer development. Although most studies focus on CC, it is important to investigate the presence of CT in other HPV-associated neoplasms. Therefore, this study aimed to summarize the main studies that investigated the presence of CT in samples of cancers associated with HPV. A systematic review of the literature was conducted according to PRISMA guidelines, with the protocol registered in PROSPERO. Searches were carried out in the PubMed, Science Direct, and LILACS databases, using specific descriptors based on MeSH and DeCS terms. The risk of bias in the included studies was assessed using the JBI platform. A total of 1,748 studies were identified, of which 12 met the eligibility criteria and were included: 8 case-control, 2 cohort, and 2 cross-sectional studies. Seven studies addressed CT in CC, with eight reporting a statistically significant association. Vulvar and anal neoplasms were cited in two and one study, respectively, with statistical significance found in only one study on vulvar cancer. CT prevalence ranged from 1.7% to 65%. The most commonly used diagnostic techniques were ELISA and MIF on liquid and cervical smear samples, and PCR, including nested and multiplex variants. Nine studies analyzed CT/HPV coinfection, with prevalence ranging from 28.9% to 97%. The findings reinforce that CT may increase the risk of cervical cancer, especially in cases of coinfection with HPV. Further studies are needed to explore this association in other HPV-related malignancies 2025-06-24T00:00:00Z https://repositorio.uema.br/jspui/handle/123456789/5469 Título: Uso de tecnologias digitais no ensino de biologia na rede pública de ensino médio em Zé Doca (MA) Abstact: This study aims to analyze how the use of digital technologies can contribute to the teaching of biology in the public high school system in Zé Doca, Maranhão. The research, of a qualitative, descriptive and exploratory nature, was conducted with active high school biology teachers, using a questionnaire as a data collection instrument. The results indicate that, although there is recognition and importance of digital technologies as pedagogical tools to make teaching more dynamic, interactive and motivating, there are still obstacles to be overcome, such as lack of continuing education, inadequate infrastructure and inequality in access to necessary technological equipment. The study also revealed that resources such as videos, animations, games and digital platforms, among others, have significant potential to improve the understanding of biological content, especially the most abstract ones. However, the effective insertion of these tools in education requires investments in teacher training, infrastructure and public policies committed to pedagogical innovation, aiming to improve and promote an education that is more contextualized to the needs of the 21st century. 2025-06-26T00:00:00Z https://repositorio.uema.br/jspui/handle/123456789/4646 Título: Interações entre Chionomesa fimbriata (aves: Trochilidae) e seus recursos florais em uma área urbana na Amazônia Maranhense, Brasil Abstact: Avian pollination plays a crucial role in maintaining biodiversity, particularly in tropical ecosystems, where many plants depend on birds for reproduction. Among pollinating birds, hummingbirds (Trochilidae) stand out as key agents, accounting for up to 15% of plant pollination in the Neotropical region, particularly in trees and shrubs. Given this, the present study aimed to investigate the interactions between Chionomesa fimbriata and its floral resources in an urban area of the Maranhão Amazon. The study was conducted in Horto Florestal, an urban green space located in the municipality of Zé Doca, Maranhão, Brazil. Fieldwork took place from October 2023 to September 2024, using the focal observation method for data collection. Five plant species visited by a single hummingbird species, Chionomesa fimbriata, were identified. None of the observed plants were ornithophilous, demonstrating that hummingbirds can utilize alternative resource sources even in environments dominated by plant species not specialized for bird pollination. The flowering phenology of the plant species varied throughout the year, with higher intensity during the dry season. Precipitation influenced visitation frequency, with lower activity during months of high rainfall. The results indicate that urbanization affects hummingbird-plant interactions, favoring generalist species and non-ornithophilous plants. The presence of plants with prolonged flowering is crucial for maintaining hummingbird populations in urban areas. Chionomesa fimbriata exhibited foraging strategies such as territoriality and high-reward foraging circuits, displaying agonistic behaviors, particularly in intraspecific interactions. The observed foraging strategies and agonistic behaviors reflect hummingbirds' adaptation to resource availability and competition in urban environments. This study underscores the importance of conserving plant diversity in urban areas to support hummingbird populations and their ecological roles 2025-02-14T00:00:00Z